About DEBKS¶

About¶

DEBKS is a toolkit for detecting differentially expressed circRNA (DEC) between two RNA-seq sample groups with replicates. The pipeline provides four modules:

merge: collect circular and linear junction counts from circRNA detection outputs
count: calculate linear junction counts from aligned RNA-seq BAM files
anno: annotate circRNAs and infer potential lengths
dec: identify DECs with an rMATS-based statistical model

DEBKS workflow

Guides¶

Installation
Usage
Example workflow
Import from CIRIquant

Citation¶

If you use DEBKS in your research, please cite:

Zelin Liu, Huiru Ding, Jianqi She, Chunhua Chen, Weiguang Zhang, Ence Yang, DEBKS: A Tool to Detect Differentially Expressed Circular RNAs, Genomics, Proteomics & Bioinformatics, 2022, 20(3):549-556, https://doi.org/10.1016/j.gpb.2021.01.003.